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Could the same benefits be translated to those without established CVD (the majority of the patient population we see in clinical practice)? CANVAS PROGRAM was supposed to answer this vital question in addition to assessing CV outcomes in those with established CVD.What was the clinical impact of CANVAS PROGRAM?The only end points in which canagliflozin came out with flying colours were MACE hospitalisation due to heart failure.MACE benefits in only those with established CVD (mimicking EMPA REG trial).No reduction in all cause mortality.No reduction in CV deaths.Significant increase in rates of fractures lower limb amputations.To summarise treating patients with canagliflozin results in:23 fewer MACE (? clinical implication: in the absence of any superiority of the individual end points), 16 fewer hospitalisation due to heart failure, at the cost of 15 more amputations per 1000 patients treated for 5 years (1).Where does that leave us with?In a desperate bid to save the molecule there is an effort to generalise the amputation risk aspect.There is no escaping the fact that the amputation fracture related issue was haunting canagliflozin well before the CANVAS PROGRAM was published (indicated by the black box warnings).What was brought out in the forefront was an EMEA observation of imbalances in the amputation rates in females in the EMPA REG trial (4). Although the EMEA statements were contradictory, they wanted to scrutinise the entire empagliflozin dapagliflozin data before painting this entire class of molecules with the same brush.In July 19th 2017, the entire empagliflozin databank from phase 2 3 EMPA REG were analysed and there was no signal of either increased amputation nor fracture risk (5).Similarly the entire dapagliflozin polled phase 2 3 data did not indicate any adverse signals related to amputation fracture (6).So where do we stand as of now?Empagliflozin remains the gold standard therapy for all type 2 diabetes patients with established CVD with a very reassuring safety profile.Dapagliflozin has also documented its CV safety in polled phase 2 3 trials. Further clarifications will be available after publication oF DECLARE TIMI 58 results.Canagliflozin has MACE benefits but not any CV or all cause mortality benefits and at the cost of increased serious adverse effects.A recent news post from a reputed newspaper quoted a medical regulatory body and suggested that the physicians practicing as “Diabetologist” should be brought under the scanner.

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Judicial Candidate Accuses Rival of Violating State Law PHYLLIS W. JORDAN, SPECIAL TO THE TIMESDriver May Have Died of Heart Attack Before CrashHUNTINGTON BEACH : March to Raise Funds for Babies WILLSON CUMMERCountywide : Banks, Cities Join in Fighting Bad Checks RENE LYNCHDeveloper Offers Santa Ana a New Space Saver School Site JON NALICK, SPECIAL TO THE TIMESCountywide : Affordable Housing Projects Advance ANNA CEKOLASANTA ANA : French Park Rentals Set for Upgrading JON NALICKThousand Oaks Homeowners at Top of Quake Relief List STEPHANIE SIMONNEWS ANALYSIS : Some Parts of Budget Will Be Tough Sell : Finances: Critics say Riordan proposal to consolidate a number of departments will reduce their effectiveness. Shippers, airlines may fight planned transfer of harbor and airport revenues.

In terms of kids, there never been an ideal world. I would argue that the essence of being a parent is preparing the child to deal with the world and with problems. People can profit in chaos, they just generally not the same people that profit in times of stability.

Law” and “The Cosby Show.” Over a four year period, more than 160 prime time episodes incorporated the campaign’s message in sub plots, scenes and dialogue. Further extending the campaign’s reach, the leading broadcast networks aired frequent public service announcements during prime time, encouraging the use of designated drivers. And, the campaign generated extensive news coverage.

When I finally did receive them, I noticed two major things: they used a smaller lens and a clear/white gasket to keep it from cracking, and the lenses they used were more grey than black, which lead to the lenses being way more transparent than I have liked.All in all not a terrible purchase, but if you want yours to retain the best look while being as functional as possible, do it through ray ban, not some outside company.Edit: they are super functional but look goofy.this is hella retardedly expensive in the US. I did this in HK and it was still sort of pricy I think it was around $150 USD?lenses are actually made by different companies. If you want the rayban glass, you can get it, with the ray ban logo and everything, but it quite pricy.

No bodyguards, no Secret Service, no subterfuge. By refusing to be a recluse, he forced people to give him some space. And he returned the favor by being a generous and gracious public figure.. This post wasn’t meant to be sympathy seeking. This was a positive moment for us. While, yes, it has been very difficult without him, this was a big step in us gaining peace with everything that has happened.

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Scorsese closes his film with the famous performance at the Manchester Free Trade Hall, when you hear a voice from the audience calling out “Judas!” Dylan leans into the microphone. “I don’t believe you,” he says. “You’re a liar.” Then he turns to address his fellow musicians.

Here is a recent study from the Massachusetts General Hospital which found people following vegan diets had the longest lifespans. The evidence is pretty strong that eating a plant based diet is healthier than one based on animal foods, and the evidence is rock solid that it at least not detrimental (which makes it a moral issue to me if I can be healthy without animal products, how can I justify continuing to buy them?). Similar to the environmental impact study I posted above, it the largest study ever of its kind..

Hutchins felt that his students and faculty needed to be reminded of what the priorities were. The purpose of a university was to develop educated and analytical thinkers, not mindlessly fritter away time on sports events. Amazingly, Hutchins’ abolition came four years after the University of Chicago’s Jay Berwanger won the very first Heisman Trophy.

As of now, the only thing a defender can do to stop Lebron from driving to the basket is be quicker than him and beating him to a spot. Lebron can walk up to 38ft from the basket, then order around a few cuts to find the open guy. Back in the day, players would start defending from half court with contact the entire way..

JOHNSON: These are reports that other agencies use to tell the FBI when classified information has been released or is being released inappropriately, potentially to agents of foreign powers or foreign governments. The goal is to get out in front of the release of classified information and stem the damage early. But there’s no word yet on whether the FBI or the Justice Department will launch any kind of investigation.

When choosing a landing net, keep the size of the fish being targeted in mind. A smaller net is easier to handle while a larger net can of course land larger fish. Also keep in mind the length of the handle. President Trump signed an executive order that halted refugees and residents from certain predominantly Muslim countries from entering the United States. Stephanie Keith/Getty ImagesBuy PhotoIn a separate statement, Homeland Security Secretary John F. Kelly was less definitive, suggesting that green card holders’ status would help them gain entry to the country but that they nonetheless would be subject to a “case by case” review.Meanwhile, Kelly’s department indicated separately Sunday that it would continue to implement Trump’s directive, even as it said it “will comply with judicial orders” issued by federal judges over the weekend, blocking enforcement of the ban to varying degrees.

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KASTE: The LAPD is betting that California law will not force the release of most body camera videos, but public records laws vary a lot around the country. In Washington State, for instance, you can request police videos in bulk. This fall the Seattle Police Department received a request for its dash cam videos all of them..

Smart’s testimony was the first in what is expected to be a 10 day competency hearing that resumes Nov. 30. Thursday’s appearance was scheduled so that Smart can leave soon for a Mormon mission. “I haven’t seen what’s in those emails but I will tell you this it’s something that he needed to do because one of the issues we’ve been dealing with is broken trust. And we’ve been kept in the dark regarding some information regarding our water. We’ve been given misinformation about the water, and the only way the governor can if he can rebuild trust, is to start doing that.

Also, how to tell pintelle from poussin, how to roast a duck and a bird that arrives by airmail. : Feasting: A Flock of Fowl Recipes : Menus: Poultry has long been a staple of the holiday banquet table. Chicken, goose, quail squab these are just a few of our favorite things.

Which brings us to “America First,” the phrase that rolls off Trump’s tongue and Twitter feed with a gleefulness that belies its distasteful history. That particular slogan rose to prominence around 1915, when President Woodrow Wilson used the phrase to defend American neutrality in World War I. Its nativist undertones lent it credibility as a Ku Klux Klan slogan, and, grounded in nationalism and xenophobia, the phrase was again famously deployed by anti Semite Charles Lindbergh to advocate for keeping America out of World War II..

Being able to pick the best camera for a specific shooting situation and computationally merge the image data from all three sensors means that the new Huawei beats the competition in virtually every category, taking the number one spots in both our Photo and Video rankings. The P20 Pro is particularly good in low light, when zooming, and for bokeh simulation, blowing its direct rivals out of the water. If you are looking for the current best camera in a smartphone, look no further..

Two of three conservatives from the San Joaquin Valley vote no. But : Politics: Razor thin victory presages rough road ahead for President agenda. Rostenkowski comes through in pinch, delivers crucial votes. What do you do when a playmate hits you? That’s an intelligence question and other things like that. They used this really bogus test to determine that she was a moron, as they said at the time. And, you know, these tests were being badly used everywhere..

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Only peer reviewed, published literature will be eligible for inclusion.Models that project only retrospectively, such as those that analyse the historical burden of disease, will be excluded from this review, as will studies that model individual smoker trajectories that do not also project population level outcomes. Additionally, animal studies, human genetics studies, and posters and abstracts without full text records will be excluded from this review. This review will be limited to English language studies.Search methods for identification of studiesA comprehensive search strategy, developed in consultation with a university librarian and group of tobacco control experts, will be used to identify eligible papers (see table 1).

Think V neck or better yet try a halter neckline. Halter dresses are fitted on top and will show off all you desire to show off. Dresses with spaghetti straps can make your shoulders appear broader, and help balance out your pear shaped figure. During this process, the form will be revised to facilitate data collection for technical and conceptual aspects of included papers.Data synthesisAfter the data are collected, we will perform a qualitative synthesis of the included studies. An initial paper will provide an overview of our findings. This overview will include a conceptual framework, based on the model objective categories we identified, that will be used to organise existing tobacco modelling studies.

What you’re feeling is natural. You feel guilty, mad at yourself, like you failed. All of those are natural emotions anybody in your situation would feel. “There was an outbreak in 2000 and it was linked to exactly this festival, with livestock being sacrificed on the streets or roads not the most hygienic of settings,” says Pigott, citing a paper from Pakistan. Before 2016, most cases in Afghanistan came from western districts. Now, they’re showing up in other areas..

With leading researchers saying smoking and other modifiable factors account for most sudden infant deaths, Jonathan Gornall asks whether it is time to put the diagnosis to bedThere are no cases of sudden infant death syndrome (SIDS) in Vanderburgh County, Indiana. “I simply don’t believe in SIDS deaths,” says chief deputy coroner Annie Groves. “If you do a complete investigation, you will find a cause of death.”Coroner Groves’s confidence may sit uncomfortably with many professionals in the United Kingdom, where even the use of the word “unascertained” in unexplained infant deaths is frowned upon because it carries “implications that the death may have been the result of neglect or abuse.”1 But in America she is not alone in her certainty.The Vanderburgh experience is one of many highlighted by a review of 40000 infant deaths between 1992 and 2004 that concludes the quality of investigations carried out into sudden infant deaths in America “varies irrationally.”2The nationwide review, conducted by the Scripps Howard News Service, found that the protocol for the investigation of sudden unexpected deaths in infancy launched by the Centers for Disease Control and Prevention in 2006 was mandatory in only seven states.

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In fact, FEAR, which I remind people stands for Fictitious Evidence Affecting Reality, even enslaves the one who is seeking to do the controlling. Anyone with that kind of lack (by which I mean coming from scarcity, fear, and inner turbulence) mindset at their core is looking for their own self worth via the vehicle of control over others. Perhaps the fear is that if the playing field was more level, their self insecurity would be exposed.

On a day to day basis, all the refugees at the camp can do is continue to pass time. They continue to walk the perimeter of the camp, isolated from outside society in the midst of a rural forest. They continue to drink sparse helpings of instant coffee, eat sparse helpings of bread provided in inadequate numbers by the Greek army, and wait until the next opportunity to pick up distributed items like soaps, winter jackets, and baby diapers.

It’s hard to understand the press reaction of the time, as in the intervening three decades music, language, culture and what society accepts has become more extreme. But for the conservative world of the mid 1970s, four letter words on TV were a shocking abuse. One councillor, representing that shock and anger articulated to him by his constituents was Cllr Ray Davies, who still represents a ward in the town..

The Pink Panther 1963Perhaps the funniest film ever made. Certainly the soundtrack written by Henry Mancini had a lot to do with its staying power. The Director was Blake Edwards and the movie starred the greatest comedian ever Peter Sellers. His selection drew an immediate rebuke from the Senate’s incoming minority leader, Sen. Charles E. “Congressman Price has proven to be far out of the mainstream of what Americans want when it comes to Medicare, the Affordable Care Act, and Planned Parenthood,” Schumer said in a statement.

National Review reports that Darryl Glenn, an African American Air Force veteran and county commissioner, appears to have a narrow edge for Tuesday night, buoyed by an inspiring speech at the state GOP convention and further aided by outside spending from conservative groups on his behalf. Texas Sen. Ted Cruz traveled to campaign with him earlier this month..

Kenneth K. Hansraj, chief of spine surgery at New York Spine Surgery Rehabilitation Medicine, says the bad posture can put up to 60 pounds of pressure on the upper spine sometimes for several hours a day, depending on how often people look at their devices.An adult’s head weighs about 10 to 12 pounds. According to Hansraj’s research, which will be published next month in Surgical Technology International, tilting the head forward just 15 degrees can increase the force on the cervical spine to 27 pounds.

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Medvedev said he was talking about states which have been traditional partners. And he added that Russia was not happy about NATO extending its reach towards Russia’s borders. Medvedev will be seeing President Obama at the resumed economic summit in April, if not before then.

At the center of the debate is an idea that would pay power generators in Texas not just for the electricity they produce, but also just for being around. It known as a capacity market. There’s a lot of nitty gritty here, but it boils down to one question: Will the state of Texas have enough power for its growing population and potentially hotter summers?.

I hope you have been satisfied with this. I repeat: I have no complaint with the press. I know there will be fierce criticism. Donald D VA 4th Yes I was proud to stand with the Parkland students at the March and will continue to work with them to bring about much needed change. I hear their outcry and deeply want to give the students and all of us what we want a safer America. McGovern, James P.

Bonner, Robert C. Attorney and federal judge in Los Angeles. Knopf)Dicoveries SUSAN SALTER REYNOLDSThe Courtly and The Crude STEVEN G. Investigators this weekend opened a probe for criminal negligence in the crash and searched Metrojet’s offices. Russia’s Federal Labor Agency announced Monday that the airline had not paid its employees in the past two months, indicating financial problems in the company. And a state owned television channel broadcast an interview with the pilot’s wife, who said her husband had complained about poor maintenance on the plane..

I don do much volunteering because,frankly, I cannot comfortably prioritize my time towards volunteer work. In other words, I lacking in altruism. That makes me a selfish mom. Smith says although the stadium was a subject ripe for coverage, he didn’t challenge his new restrictions and left it alone. At a journalism conference last weekend, however, Moyer, the new editor, publicly acknowledged that Smith was barred from writing about the Adelsons and their interests. Attendees tweeted out those remarks.

But sentencing reform advocates say the tough crime policies went too far. The nation began incarcerating people at a higher rate than any other country jailing 25percent of the world’s prisoners at a cost of $80billion a year. The nation’s prison and jail population more than quadrupled from 500,000 in 1980 to 2.2million in 2015, filled with mostly black men strapped with lengthy prison sentences 10 or 20 years, sometimes life without parole for a first drug offense..

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Muhammad had agreed to a court ordered MRI, but objected that the X ray was never raised. According to The Post, Muhammad was restrained by the wrists and ankles and never became violent. The stun belt was apparently used to punish him and force him to conform to the wishes of the guards.

Trump’s campaign aides have already declared that he’s keeping anenemies list, and that he and they fantasize about retribution. Giuliani had no qualms about using his power as the mayor of New York to settle personal and political grievances. Now imagine Giuliani settling scores his and Trump’s with the vast resources of the Justice Departmentat his disposal.

The 6 11 center is Tyrell Blair, a legit big time shot blocker who has the ability to score 15 points per game but who, on some nights, is offensively invisible. He is a relatively late bloomer whose best basketball is ahead of him. I’m not saying there is an NBA in his future, but I will tell you that there is indeed a country for him somewhere.

This is about ignorance. It’s about ignorance about the LGBTQ community. It’s about ignorance about God’s love for everyone. The findings foreshadow continued strife within the Republican coalition, as establishment and tea party wings vie for superiority. What the survey cannot predict is how the damage to the GOP will affect its chances of winning control of the Senate or holding its House majority in 2014. Democrats have an eight point advantage in House races among voters nationally, according to the poll, but based on history, that lead is not predictive of a change in House majority..

Critical battleground states broke Trump’s way. Delegate rich Ohio, Florida, Pennsylvania and Wisconsin moved to the Republican candidate. Many polls failed to predict those shifts, leaving the crowds at Trump’s party in New York momentarily puzzled, then celebratory.

Marine officials have said for months that they did not want to lower the standards already in place, but would adhere to Panetta’s 2013 directive, which called for developing new gender neutral standards for each job. A spokesman for the secretary, Navy Capt. Patrick McNally, said Friday that “in many cases there were no standards, or they were arbitrarily set.”.

The trouble is, the Wells report was never going to get past the lack of accurate or even measurable data. Referee Anderson also recalls that two gauges were available, one of which gave higher readings. Which one did he use? He thinks he used the higher one but he didn’t write that down either.

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There have been more than 3,600 wildfires in California so far this year more than a thousand fires over the average. But so far, fire crews have been able to jump on most of them before they get big. Nationally, the picture is a little better. Monday night onAll In with Chris Hayes: New York City stop and frisk policy has sparked a national discussion about security, justice and racial profiling. New York Police Commissioner Ray Kelly and Mayor Michael Bloomberg have been on a media blitz defending the controversial program from critics who support a federal judge decision that the practice is unconstitutional. Mayor Bloomberg wrote an op ed in Monday Washington Postdefending stop and frisk, whileDemocratic front runner for mayor Bill de Blasio doubled down on his opposition to the program in a new ad released Monday..

Phillip)School shooting may not bring change to gun loving TexasAUSTIN, Texas (AP) Texas has more than 1.2 million licensed handgun owners who can openly carry their weapons in public. The state hosted the National Rifle Association annual meeting two weeks ago. And until Monday, the governor re election website was raffling off a shotgun.

Shortly before nightfall, Israel carried out a series of airstrikes in the northern Gaza town of Beit Lahia. Hamas’ Al Aqsa TV station reported four airstrikes in a 10 minute span, and a large plume of black smoke could be seen over the area from the Israeli border. There were no immediate reports of casualties..

10 Apr 2018Actress Deepika Singh is currently in the best phase of life. The actress who took a sabbatical from work after her hit show Diya Aur Baati Hum went off air, is all set to spring back into action.Bigg Boss 10’s Monalisa and husband Vikrant Singh Rajpoot to start a family?07 Jun 2018Actress Monalisa and actor husband Vikrant made headlines for getting married on the reality show Bigg Boss 10.Karan Wahi kick starts his pre birthday celebrations with Asha Negi and Rahul Sharma in Cape Town07 Jun 2018The TV host actor anchor Karan Wahi has won hearts with his performances in the popular series Remix and then went on to become quite popular among the masses.Bigg Boss 11’s Hina Khan and Sapna Chaudhary’s dance moves will leave you asking for more31 May 2018Bigg Boss season 11 contestants, Hina Khan and Sapna Chaudhary, recently staged dance performances in separate events.Sanjeeda Sheikh offers prayers at the Golden Temple in the holy month of Ramzan24 May 2018Television actress Sanjeeda Sheikh, who is on a mini vacation to Amritsar, offered prayers at the Golden temple.Dipika Kakar celebrates first Ramzan with Shoaib Ibrahim after marriage23 May 2018Dipika Kakar celebrated her first roza with her husband Shoaib Ibrahim after marriage.Ravi Dubey: There will be no bigger moment than to work with Sargun22 May 2018Jamai Raja actor Ravi Dubey and Sargun Mehta are one of the most loved couples of the small screen.If I perform stunts despite being heavyweight, would call myself an all rounder: Bharti Singh on Khatron Ke Khiladi 917 May 2018The reality show Khatron Ke Khiladi is going to return to TV now with its ninth season.Shoaib Ibrahim Dipika Kakar twinning in white is adorable16 May 2018Small screen’s romantic couple Shoaib Ibrahim and his wife Dipika Kakar, who tied the knot in February this year, often post their PDA pictures on social media platforms.Divyanka Tripathi gets teary eyed while talking about her relationship with Ssharad Malhotra08 May 2018Yeh Hai Mohabbatein actress Divyanka Tripathi recently shot for an episode of Rajeev Khandelwal’s new show Juzzbaatt. The actress, who appeared with her husband Vivek Dahiya on the show, got teary eyed during one of the segments when the host asked her about heartbreak.Nach Baliye fame Vinod Thakur admitted to hospital in a serious condition29 Apr 2018Nach Baliye fame Vinod Thakur recently collapsed while on his way to the Gateway of India.On International Dance Day, Reality TV grads: Dance reality shows changed our lives by giving us a platform22 Apr 2018If there is one thing that people don’t know about Divyanka Tripathi and Vivek Dahiya’s love story, it is that they met immediately after their individual break ups, and soon fell for each other.

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Another reason is that beer and exercise don’t go together. Doing as little as possible and drinking beer go together. People usually drink beer while they are taking it easy.. 2012 2017: More lines here and there from both Drake and Pusha aimed at each other, cba to find the specific tracks ATM. While Drake wins the beef in most peoples eyes, Meek left a dent in Drake legacy forever. If you don write your own rhymes, you can claim you the best (in rap culture)..

“I have this witch hunt constantly going on,” Trump said. “That is a whole new level of unfairness,” he added, leaving no doubt that he views Monday’s actions as a personal affront. Trump called Cohen “a good man” and went on to criticize Attorney General Jeff Sessions, saying he had made “a very terrible mistake for the country” by recusing himself from the Russia probe..

Third, the Flynn court documents confirm that Flynn signed his plea agreement only on Thursday just one day before his court appearance Friday. The story of the special counsel investigation is very much playing out in real time, before the eyes of the public. So in a sense, Flynn’s plea restarts the clock on the imbroglio, or shifts it into a new phase.

Wouldn say that discoveries are very frequent, but they do occur. Titian was prolific and had a very long career around 70 years so it is reasonable to expect new works to turn up from time to time, especially relatively minor ones like portraits and single figure subjects. Titian Mistress seems to me a beautiful late painting.

Aside from the theatrics, the real issue is the 1996 elections. Demands Yemen Halt Attack on Rebel City Aden : Mideast: Civilian casualties, water shortages prompt Security Council to urge a cease fire. But angry rush hour drivers blare horns and shout curses.

That had always been our goal. The Activision thing came together very quickly. If you look at the US and Europe, there are very few publishers doing what we did, building hardware as well as software. Lou Dobbs abruptly calls it quits on his CNN broadcast Wednesday. Now Dobbs, who has been somewhat of a lightening rod for his outspoken views on illegal, he didnt say what his next move would be but quote, “is considering a number of options and directions,” unquote. And I’m sure there are a lot of Latinos that wouldnt mind telling him where to go and how to get there..

Upon its debut, “Rolling The R’s” stunned readers and critics alike with its profane and almost too true portrayal of a group of teens finding themselves in late 1970s Honolulu, grappling with sexuality, teachers who play favorites, adults who don’t get it. It’s full of drama, fun and pain, all told with a dazzling array of literary styles. For all those reasons, the Asian American Literary Review is honoring the book with a special 20th anniversary edition [POST BROADCAST CORRECTION: We incorrectly said that The Asian American Literary Review is honoring the book with a special 20th anniversary edition.